Crystal structure of a Staphylococcus aureus protein A domain complexed with the Fab fragment of a human IgM antibody: Structural basis for recognition of B-cell receptors and superantigen activity

Staphylococcus aureus produces a virulence factor, protein A (SpA), that contains five homologous Ig-binding domains. The interactions of SpA with the Fab region of membrane-anchored Igs can stimulate a large fraction of B cells, contributing to lymphocyte clonal selection. To understand the molecul...

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Bibliographic Details
Main Authors: Graille, Marc, Stura, Enrico A., Corper, Adam L., Sutton, Brian J., Taussig, Michael J., Charbonnier, Jean-Baptiste, Silverman, Gregg J.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 2000
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC25840/
https://ncbi.nlm.nih.gov/pubmed/10805799
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