Protection against experimental pseudomembranous colitis in gnotobiotic mice by use of monoclonal antibodies against Clostridium difficile toxin A.

The pathogenicity of Clostridium difficile is due to the production of two toxins (toxins A and B). We prepared monoclonal antibodies against toxin A and determined whether axenic mice passively immunized with the monoclonal antibodies were protected against C. difficile disease. The mice were kept...

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Pubblicato in:	Infect Immun
Autori principali:	Corthier, G, Muller, M C, Wilkins, T D, Lyerly, D, L'Haridon, R
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1991
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC258389/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1900059/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.59.3.1192-1195.1991
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