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Incorporation of Membrane-Anchored Flagellin into Influenza Virus-Like Particles Enhances the Breadth of Immune Responses

We have designed a membrane-anchored form of the Toll-like receptor 5 ligand flagellin, the major proinflammatory determinant of enteropathogenic Salmonella, which was found to be glycosylated and expressed on cell surfaces. A chimeric influenza virus-like particle (cVLP) vaccine candidate containin...

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Bibliografiske detaljer
Main Authors: Wang, Bao-Zhong, Quan, Fu-Shi, Kang, Sang-Moo, Bozja, Jadranka, Skountzou, Ioanna, Compans, Richard W.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2008
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2583664/
https://ncbi.nlm.nih.gov/pubmed/18786995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01076-08
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