Vibrio cholerae Flagellins Induce Toll-Like Receptor 5-Mediated Interleukin-8 Production through Mitogen-Activated Protein Kinase and NF-κB Activation

Vaccine reactogenicity has complicated the development of safe and effective live, oral cholera vaccines. Δctx Vibrio cholerae mutants have been shown to induce inflammatory diarrhea in volunteers and interleukin-8 (IL-8) production in cultured intestinal epithelial cells. Bacterial flagellins are k...

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Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Harrison, Lisa M., Rallabhandi, Prasad, Michalski, Jane, Zhou, Xin, Steyert, Susan R., Vogel, Stefanie N., Kaper, James B.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology (ASM) 2008
Ämnen:
Host Response and Inflammation
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2583592/
https://ncbi.nlm.nih.gov/pubmed/18809662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00843-08
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