Antibodies to Capsular Polysaccharide and Clumping Factor A Prevent Mastitis and the Emergence of Unencapsulated and Small-Colony Variants of Staphylococcus aureus in Mice

The pathogenesis of Staphylococcus aureus infections is influenced by multiple virulence factors that are expressed under variable conditions, and this has complicated the design of an effective vaccine. Clinical trials that targeted the capsule or clumping factor A (ClfA) failed to protect the reci...

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Bibliographic Details
Main Authors: Tuchscherr, Lorena P. N., Buzzola, Fernanda R., Alvarez, Lucía P., Lee, Jean C., Sordelli, Daniel O.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2008
Subjects:
Microbial Immunity and Vaccines
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2583566/
https://ncbi.nlm.nih.gov/pubmed/18809660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00874-08
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