Interleukin-4-Promoted T Helper 2 Responses Enhance Nippostrongylus brasiliensis-Induced Pulmonary Pathology

The role of CD4(+) T-cell interleukin-4 (IL-4) receptor alpha (IL-4Rα) expression in T helper 2 (TH2) immune responses has not been defined. To examine this role, we infected CD4(+) T-cell IL-4Rα knockout (KO) mice with the parasitic nematode Nippostrongylus brasiliensis, which induces strong host T...

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Autors principals: Mearns, Helen, Horsnell, William G. C., Hoving, J. Claire, Dewals, Benjamin, Cutler, Antony J., Kirstein, Frank, Myburgh, Elmarie, Arendse, Berenice, Brombacher, Frank
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2008
Matèries:
Fungal and Parasitic Infections
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2583554/
https://ncbi.nlm.nih.gov/pubmed/18809669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00210-08
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