Monoclonal antibody to an endogenous bufadienolide, marinobufagenin, reverses preeclampsia-induced Na/K-ATPase inhibition and lowers blood pressure in NaCl-sensitive hypertension

BACKGROUND: Levels of marinobufagenin (MBG), an endogenous bufadienolide Na/K-ATPase (NKA) inhibitor, increase in preeclampsia and in NaCl-sensitive hypertension. METHODS: We tested a 3E9 monoclonal anti-MBG antibody (mAb) for the ability to lower blood pressure (BP) in NaCl-sensitive hypertension a...

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Main Authors: Fedorova, Olga V., Simbirtsev, Andrey S., Kolodkin, Nikolai I., Kotov, Alexander Y., Agalakova, Natalia I., Kashkin, Vladimir A., Tapilskaya, Natalia I., Bzhelyansky, Anton, Reznik, Vitaly A., Frolova, Elena V., Nikitina, Elena R., Budny, Georgy V., Longo, Dan L., Lakatta, Edward G., Bagrov, Alexei Y.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2583455/
https://ncbi.nlm.nih.gov/pubmed/19008721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/HJH.0b013e328312c86a
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