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Crystal Structure and Mechanism of the Escherichia coli ArnA (PmrI) Transformylase Domain. An Enzyme for Lipid A Modification with 4-Amino-4-deoxy-L-arabinose and Polymyxin Resistance,
Gram-negative bacteria have evolved mechanisms to resist the bactericidal action of cationic antimicrobial peptides of the innate immune system and antibiotics such as polymyxin. The strategy involves the addition of the positively charged sugar 4-amino-4-deoxy-L-arabinose (Ara4N) to lipid A in thei...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2005
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2583347/ https://ncbi.nlm.nih.gov/pubmed/15807526 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi047384g |
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