Asymmetry in the Lipid Affinity of Bihelical Amphipathic Peptides: A STRUCTURAL DETERMINANT FOR THE SPECIFICITY OF ABCA1-DEPENDENT CHOLESTEROL EFFLUX BY PEPTIDES

ApoA-I contains a tandem array of amphipathic helices with varying lipid affinity, which are critical in its ability to bind and remove lipids from cells by the ABCA1 transporter. In this study, the effect of asymmetry in the lipid affinity of amphipathic helices in a bihelical apoA-I mimetic peptid...

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Autors principals: Sethi, Amar A., Stonik, John A., Thomas, Fairwell, Demosky, Steve J., Amar, Marcelo, Neufeld, Edward, Brewer, H. Bryan, Davidson, W. Sean, D'Souza, Wilissa, Sviridov, Dmitri, Remaley, Alan T.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2008
Matèries:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2583319/
https://ncbi.nlm.nih.gov/pubmed/18805791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804461200
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