The Nociceptor Ion Channel TRPA1 Is Potentiated and Inactivated by Permeating Calcium Ions

The transient receptor potential A1 (TRPA1) channel is the molecular target for environmental irritants and pungent chemicals, such as cinnamaldehyde and mustard oil. Extracellular Ca(2+) is a key regulator of TRPA1 activity, both potentiating and subsequently inactivating it. In this report, we pro...

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Bibliografiske detaljer
Main Authors: Wang, Yuanyuan Y., Chang, Rui B., Waters, Hang N., McKemy, David D., Liman, Emily R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2008
Fag:
Membrane Transport, Structure, Function, and Biogenesis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2583289/
https://ncbi.nlm.nih.gov/pubmed/18775987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803568200
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