High Resolution Crystal Structure of an Engineered Human β(2)-Adrenergic G protein-Coupled Receptor

G protein-coupled receptors comprise the largest family of eukaryotic signal transduction proteins that communicate across the membrane. We report the crystal structure of a human β(2)-adrenergic receptor—T4 lysozyme fusion protein bound to the partial inverse agonist carazolol at 2.4 Å resolution....

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Hlavní autoři: Cherezov, Vadim, Rosenbaum, Daniel M., Hanson, Michael A., Rasmussen, Søren G. F., Thian, Foon Sun, Kobilka, Tong Sun, Choi, Hee-Jung, Kuhn, Peter, Weis, William I., Kobilka, Brian K., Stevens, Raymond C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2583103/
https://ncbi.nlm.nih.gov/pubmed/17962520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1150577
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