Behavioral alterations associated with apoptosis and down-regulation of presenilin 1 in the brains of p53-deficient mice

Presenilin 1 (PS1) expression is repressed by the p53 tumor suppressor. As shown herein, wild-type PS1 is an effective antiapoptotic molecule capable of significantly inhibiting p53-dependent and p53-independent cell death. We analyzed, at the functional and molecular levels, the brains of p53 knock...

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Hauptverfasser: Amson, Robert, Lassalle, Jean-Michel, Halley, Hélène, Prieur, Sylvie, Lethrosne, Florence, Roperch, Jean-Pierre, Israeli, David, Gendron, Marie-Claude, Duyckaerts, Charles, Checler, Frédéric, Dausset, Jean, Cohen, Daniel, Oren, Moshe, Telerman, Adam
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences 2000
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC25831/
https://ncbi.nlm.nih.gov/pubmed/10805794
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