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Generation of a ‘Humanized’ hCYP1A1_1A2_Cyp1a1/1a2(−/−)_Ahr(d) Mouse Line Harboring the Poor-Affinity Aryl Hydrocarbon Receptor
Herein we describe generation of the hCYP1A1_1A2_Cyp1a1/1a2(−/−)_Ahr(d) mouse line, which carries human functional CYP1A1 and CYP1A2 genes in the absence of mouse Cyp1a1 and Cyp1a2 genes, in a (>99.8%) background of the C57BL/6J genome and harboring the poor-affinity aryl hydrocarbon receptor (AH...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2582963/ https://ncbi.nlm.nih.gov/pubmed/18814841 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2008.09.068 |
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