Modulation of endotoxin-induced monokine release in human monocytes by lipid A partial structures that inhibit binding of 125I-lipopolysaccharide.

We have previously shown that the synthetic tetraacyl precursor Ia (compound 406, LA-14-PP, or lipid IVa) was not able to induce the production of tumor necrosis factor, interleukin-1, and interleukin-6 in human monocytes but strongly antagonized lipopolysaccharide (LPS)-induced formation of these m...

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Bibliographic Details
Main Authors: Ulmer, A J, Feist, W, Heine, H, Kirikae, T, Kirikae, F, Kusumoto, S, Kusama, T, Brade, H, Schade, U, Rietschel, E T
Format: Artigo
Language:Inglês
Published: 1992
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC258290/
https://ncbi.nlm.nih.gov/pubmed/1280625
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