Modulation of endotoxin-induced monokine release in human monocytes by lipid A partial structures that inhibit binding of 125I-lipopolysaccharide.

We have previously shown that the synthetic tetraacyl precursor Ia (compound 406, LA-14-PP, or lipid IVa) was not able to induce the production of tumor necrosis factor, interleukin-1, and interleukin-6 in human monocytes but strongly antagonized lipopolysaccharide (LPS)-induced formation of these m...

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Detalhes bibliográficos
Publicado no:Infect Immun
Main Authors: Ulmer, A J, Feist, W, Heine, H, Kirikae, T, Kirikae, F, Kusumoto, S, Kusama, T, Brade, H, Schade, U, Rietschel, E T
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1992
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC258290/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1280625/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.60.12.5145-5152.1992
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