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Construction of a diphtheria toxin A fragment-C180 peptide fusion protein which elicits a neutralizing antibody response against diphtheria toxin and pertussis toxin.

A genetically engineered gene fusion was constructed which encoded a nontoxic derivative of the A fragment of diphtheria toxin joined to the C180 peptide of the S1 subunit of pertussis toxin. The product of this gene fusion, termed the DTA-C180 protein, was purified from the periplasm of Escherichia...

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Detalhes bibliográficos
Publicado no:Infect Immun
Main Authors: Barbieri, J T, Armellini, D, Molkentin, J, Rappuoli, R
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1992
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC258279/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1452339/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.60.12.5071-5077.1992
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