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In vivo evaluation of PhiC31 recombinase activity using a self-excision cassette

Gene targeting allows precise tailoring of the mouse genome such that desired modifications can be introduced under precise temporal and spatial control. This can be achieved through the use of site-specific recombinases, which mediate deletion or inversion of genomic DNA flanked by recombinase-spec...

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Bibliographic Details
Main Authors: Sangiorgi, Eugenio, Shuhua, Zhang, Capecchi, Mario R.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2008
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2582622/
https://ncbi.nlm.nih.gov/pubmed/18829714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn627
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