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TRANSGENIC OVEREXPRESSION OF INSULIN RECEPTOR SUBSTRATE 1 IN HEPATOCYTES ENHANCES HEPATOCELLULAR PROLIFERATION IN YOUNG MICE ONLY
The insulin receptor substrate-1 (IRS-1) is a multisite docking protein which plays a central part in the signal transduction of growth factors such as insulin and insulin-like growth factors (IGF-1 and IGF-2). It is found to be frequently overexpressed in human hepatocellular carcinoma (HCC). To st...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2008
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2582588/ https://ncbi.nlm.nih.gov/pubmed/18631251 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1872-034X.2008.00396.x |
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