Inflammatory Cytokines Inhibit ADAMTS13 Synthesis in Hepatic Stellate Cells and Endothelial Cells

Eitemau Tebyg

• Apical sorting of ADAMTS13 in vascular endothelial cells and Madin-Darby canine kidney cells depends on the CUB domains and their association with lipid rafts
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• Correction of ADAMTS13 Deficiency by In Utero Gene Transfer of Lentiviral Vector encoding ADAMTS13 Genes
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• Correction of murine ADAMTS13 deficiency by hematopoietic progenitor cell–mediated gene therapy
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• von Willebrand factor cleaved from endothelial cells by ADAMTS13 remains ultra large in size
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  Cyhoeddwyd: (2009)
• Increased ADAMTS-13 proteolytic activity in rat hepatic stellate cells upon activation in vitro and in vivo
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  Cyhoeddwyd: (2006)