Deletion of the chloride transporter Slc26a9 causes loss of tubulovesicles in parietal cells and impairs acid secretion in the stomach

Slc26a9 is a recently identified anion transporter that is abundantly expressed in gastric epithelial cells. To study its role in stomach physiology, gene targeting was used to prepare mice lacking Slc26a9. Homozygous mutant (Slc26a9(−/−)) mice appeared healthy and displayed normal growth. Slc26a9 d...

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Autores principales: Xu, Jie, Song, Penghong, Miller, Marian L., Borgese, Frank, Barone, Sharon, Riederer, Brigitte, Wang, Zhaohui, Alper, Seth L., Forte, John G., Shull, Gary E., Ehrenfeld, Jordi, Seidler, Ursula, Soleimani, Manoocher
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2008
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2582584/
https://ncbi.nlm.nih.gov/pubmed/19004773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0800616105
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