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Antigen-mediated T cell expansion regulated by parallel pathways of death

T cells enigmatically require caspase-8, an inducer of apoptosis, for antigen-driven expansion and effective antiviral responses, and yet the pathways responsible for this effect have been elusive. A defect in caspase-8 expression does not affect progression through the cell cycle but causes an abno...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Ch'en, Irene L., Beisner, Daniel R., Degterev, Alexei, Lynch, Candace, Yuan, Junying, Hoffmann, Alexander, Hedrick, Stephen M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2008
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2582294/
https://ncbi.nlm.nih.gov/pubmed/18981423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0808043105
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