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PTP1B is a negative regulator of interleukin 4–induced STAT6 signaling

Protein tyrosine phosphatase 1B (PTP1B) is a ubiquitously expressed enzyme shown to negatively regulate multiple tyrosine phosphorylation-dependent signaling pathways. PTP1B can modulate cytokine signaling pathways by dephosphorylating JAK2, TYK2, and STAT5a/b. Herein, we report that phosphorylated...

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Autori principali: Lu, Xiaoqing, Malumbres, Raquel, Shields, Benjamin, Jiang, Xiaoyu, Sarosiek, Kristopher A., Natkunam, Yasodha, Tiganis, Tony, Lossos, Izidore S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2008
Soggetti:
Immunobiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2582009/
https://ncbi.nlm.nih.gov/pubmed/18716132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-03-148726
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