IRF8 regulates B-cell lineage specification, commitment, and differentiation

PU.1, IKAROS, E2A, EBF, and PAX5 comprise a transcriptional network that orchestrates B-cell lineage specification, commitment, and differentiation. Here we identify interferon regulatory factor 8 (IRF8) as another component of this complex, and show that it also modulates lineage choice by hematopo...

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Autors principals: Wang, Hongsheng, Lee, Chang Hoon, Qi, Chenfeng, Tailor, Prafullakumar, Feng, Jianxun, Abbasi, Sadia, Atsumi, Toru, Morse, Herbert C.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2008
Matèries:
Hematopoiesis and Stem Cells
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2581985/
https://ncbi.nlm.nih.gov/pubmed/18799728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-01-129049
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