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A functional proline switch in cytochrome P450(cam)
The two-protein complex between putidaredoxin (Pdx) and cytochrome P450(cam) (CYP101) is the catalytically competent species for camphor hydroxylation by CYP101. We detected a conformational change in CYP101 upon binding of Pdx that re-orients bound camphor appropriately for hydroxylation. Experimen...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2008
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2581830/ https://ncbi.nlm.nih.gov/pubmed/18513977 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2008.03.011 |
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