Microdystrophin Gene Therapy of Cardiomyopathy Restores Dystrophin-Glycoprotein Complex and Improves Sarcolemma Integrity in the Mdx Mouse Heart

BACKGROUND: More than 90% of Duchenne muscular dystrophy (DMD) patients develop cardiomyopathy, and many die of cardiac failure. Despite tremendous progress in skeletal muscle gene therapy, few attempts have been made to treat cardiomyopathy. Microdystrophin genes are shown to correct skeletal muscl...

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Autores principales: Yue, Yongping, Li, Zhenbo, Harper, Scott Q., Davisson, Robin L., Chamberlain, Jeffrey S., Duan, Dongsheng
Formato: Artigo
Lenguaje:Inglês
Publicado: 2003
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2581719/
https://ncbi.nlm.nih.gov/pubmed/12952841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/01.CIR.0000089371.11664.27
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