Distinct roles of the NH(2)- and COOH-terminal domains of the protein inhibitor of activated signal transducer and activator of transcription (STAT) 1 (PIAS1) in cytokine-induced PIAS1–Stat1 interaction

STATs are activated by tyrosine phosphorylation on cytokine stimulation. A tyrosine-phosphorylated STAT forms a functional dimer through reciprocal Src homology 2 domain (SH2)–phosphotyrosyl peptide interactions. IFN treatment induces the association of PIAS1 and Stat1, which results in the inhibiti...

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Publikašuvnnas:	Proc Natl Acad Sci U S A
Váldodahkkit:	Liao, Jiayu, Fu, Yubin, Shuai, Ke
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	National Academy of Sciences 2000
Fáttát:	Biological Sciences
Liŋkkat:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC25817/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10805787/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.10.5267
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