Cross-talk between the Akt and NF-κB Signaling Pathways Inhibits MEHP-Induced Germ Cell Apoptosis

Phthalates are ubiquitous contaminants that target the testis during in utero and postnatal development. The PI3K/Akt and nuclear factor kappa B (NF-κB) signaling pathways have been implicated in germ cell survival following testicular injury. Here we observe that Akt kinase activity increases in th...

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Bibliographic Details
Main Authors: Rogers, Rachel, Ouellet, Gregory, Brown, Caitlin, Moyer, Ben, Rasoulpour, Teresa, Hixon, Mary
Format: Artigo
Language:Inglês
Published: Oxford University Press 2008
Subjects:
Reproductive and Developmental Toxicology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2581679/
https://ncbi.nlm.nih.gov/pubmed/18755736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfn186
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