Impaired Cardiac Contractility in Mice Lacking Both the AE3 [Formula: see text] Exchanger and the NKCC1 Na(+)-K(+)-2Cl(–) Cotransporter: EFFECTS ON Ca(2+) HANDLING AND PROTEIN PHOSPHATASES

To analyze the cardiac functions of AE3, we disrupted its gene (Slc4a3) in mice. [Formula: see text] exchange coupled with Na(+)-dependent acid extrusion can mediate pH-neutral Na(+) uptake, potentially affecting Ca(2+) handling via effects on Na(+)/Ca(2+) exchange. AE3 null mice appeared normal, ho...

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Main Authors: Prasad, Vikram, Bodi, Ilona, Meyer, Jamie W., Wang, Yigang, Ashraf, Muhammad, Engle, Sandra J., Doetschman, Thomas, Sisco, Karena, Nieman, Michelle L., Miller, Marian L., Lorenz, John N., Shull, Gary E.
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2008
主題:
Membrane Transport, Structure, Function, and Biogenesis
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2581574/
https://ncbi.nlm.nih.gov/pubmed/18779325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803706200
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