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Characterization of rhodosaminyl-transfer by the AknS/AknT glycosylation complex and its use in reconstituting the biosynthetic pathway of Aclacinomycin A

The tetracyclic core of anthracycline natural products with antitumor activity such as aclacinomycin A are tailored during biosynthesis by regioselective glycosylation. We report the first synthesis of TDP-L-rhodosamine and demonstrate that the glycosyltransferase AknS transfers L-rhodosamine to the...

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Detaylı Bibliyografya
Asıl Yazarlar: Leimkuhler, Catherine, Fridman, Micha, Lupoli, Tania, Walker, Suzanne, Walsh, Christopher T., Kahne, Daniel
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2007
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2580061/
https://ncbi.nlm.nih.gov/pubmed/17685523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja072909o
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