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Chaperonin chamber accelerates protein folding through passive action of preventing aggregation

The original experiments reconstituting GroEL–GroES-mediated protein folding were carried out under “nonpermissive” conditions, where the chaperonin system was absolutely required and substrate proteins could not achieve the native state if diluted directly from denaturant into solution. Under “perm...

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Hlavní autoři: Apetri, Adrian C., Horwich, Arthur L.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2579888/
https://ncbi.nlm.nih.gov/pubmed/18987317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0809794105
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