Investigation of Debio 025, a cyclophilin inhibitor, in the dystrophic mdx mouse, a model for Duchenne muscular dystrophy

BACKGROUND AND PURPOSE: Duchenne muscular dystrophy (DMD) is a severe muscle wasting disorder caused by the absence of the cytoskeletal protein dystrophin. This leads to muscle cell death accompanied by chronic inflammation. Cyclosporin A (CsA) is a powerful immunosuppressive drug, which has been pr...

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Detalles Bibliográficos
Autores principales: Reutenauer, J, Dorchies, O M, Patthey-Vuadens, O, Vuagniaux, G, Ruegg, U T
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2008
Materias:
Research Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2579666/
https://ncbi.nlm.nih.gov/pubmed/18641676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjp.2008.285
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