HIV-1 Tat Activates Neuronal Ryanodine Receptors with Rapid Induction of the Unfolded Protein Response and Mitochondrial Hyperpolarization

Neurologic disease caused by human immunodeficiency virus type 1 (HIV-1) is ultimately refractory to highly active antiretroviral therapy (HAART) because of failure of complete virus eradication in the central nervous system (CNS), and disruption of normal neural signaling events by virally induced...

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Detalhes bibliográficos
Main Authors: Norman, John P., Perry, Seth W., Reynolds, Holly M., Kiebala, Michelle, De Mesy Bentley, Karen L., Trejo, Margarita, Volsky, David J., Maggirwar, Sanjay B., Dewhurst, Stephen, Masliah, Eliezer, Gelbard, Harris A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2579580/
https://ncbi.nlm.nih.gov/pubmed/19009018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0003731
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