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Evolution of MDA-5/RIG-I-dependent innate immunity: Independent evolution by domain grafting
Type I Interferons (IFNs) are requisite components in antiviral innate immunity. Classically, a Toll-like receptor-dependent pathway induces type I interferons. However, recent recognition of melanoma differentiation associated gene-5 (MDA-5) and retinoic acid inducible gene-I (RIG-I) as primary sen...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2579374/ https://ncbi.nlm.nih.gov/pubmed/18971330 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804956105 |
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