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Urea denaturation by stronger dispersion interactions with proteins than water implies a 2-stage unfolding
The mechanism of denaturation of proteins by urea is explored by using all-atom microseconds molecular dynamics simulations of hen lysozyme generated on BlueGene/L. Accumulation of urea around lysozyme shows that water molecules are expelled from the first hydration shell of the protein. We observe...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2008
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2579355/ https://ncbi.nlm.nih.gov/pubmed/18957546 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0808427105 |
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