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Mechanism of thermal decomposition of carbamoyl phosphate and its stabilization by aspartate and ornithine transcarbamoylases
Carbamoyl phosphate (CP) has a half-life for thermal decomposition of <2 s at 100 °C, yet this critical metabolic intermediate is found even in organisms that grow at 95–100 °C. We show here that the binding of CP to the enzymes aspartate and ornithine transcarbamoylase reduces the rate of therma...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
2008
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2579353/ https://ncbi.nlm.nih.gov/pubmed/18971327 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0809631105 |
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