Assembly of τ protein into Alzheimer paired helical filaments depends on a local sequence motif ((306)VQIVYK(311)) forming β structure

We have searched for a minimal interaction motif in τ protein that supports the aggregation into Alzheimer-like paired helical filaments. Digestion of the repeat domain with different proteases yields a GluC-induced fragment comprising 43 residues (termed PHF43), which represents the third repeat of...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: von Bergen, M., Friedhoff, P., Biernat, J., Heberle, J., Mandelkow, E.-M., Mandelkow, E.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The National Academy of Sciences 2000
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC25793/
https://ncbi.nlm.nih.gov/pubmed/10805776
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk