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Strengths and Limitations of Genetic Mouse Models of Parkinson’s Disease
Genetic mouse models based on α-synuclein overexpression are particularly compelling because abnormal accumulation of α-synuclein occurs in sporadic Parkinson’s disease (PD). Our laboratory has characterized a mouse overexpressing wild-type human α-synuclein under the Thy1 promoter, which confers br...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2577895/ https://ncbi.nlm.nih.gov/pubmed/18585084 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.parkreldis.2008.04.004 |
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