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Reduced purifying selection prevails over positive selection in human copy number variant evolution
Copy number variation is a dominant contributor to genomic variation and may frequently underlie an individual’s variable susceptibilities to disease. Here we question our previous proposition that copy number variants (CNVs) are often retained in the human population because of their adaptive benef...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Cold Spring Harbor Laboratory Press
2008
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2577867/ https://ncbi.nlm.nih.gov/pubmed/18687881 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.077289.108 |
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