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The paclitaxel site in tubulin probed by site-directed mutagenesis of Saccharomyces cerevisiae β-tubulin
Previously we created a paclitaxel-sensitive strain of Saccharomyces cerevisiae by mutating five amino acid residues in β-tubulin in a strain that has a decreased level of the ABC multidrug transporters. We have used site-directed mutagenesis to examine the relative importance of the five residues i...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2577837/ https://ncbi.nlm.nih.gov/pubmed/18570892 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2008.06.013 |
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