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The EM structure of a type I interferon – receptor complex reveals a novel mechanism for cytokine signaling
Type I interferons have pleiotropic effects, including antiviral, antiproliferative and immunomodulatory responses. All type I interferons bind to a shared receptor consisting of the two transmembrane proteins ifnar1 and ifnar2. We used negative stain electron microscopy to calculate a three-dimensi...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2007
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2577817/ https://ncbi.nlm.nih.gov/pubmed/18252254 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2007.12.005 |
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