Species-specific regulation of PXR/CAR/ER-target genes in the mouse and rat liver elicited by o, p'-DDT

BACKGROUND: Dichlorodiphenyltrichloroethane (DDT) is a persistent estrogenic organochlorine pesticide that is a rodent hepatic tumor promoter, with inconclusive carcinogenicity in humans. We have previously reported that o, p'-DDT elicits primarily PXR/CAR-mediated activity, rather than ER-medi...

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Detalhes bibliográficos
Main Authors: Kiyosawa, Naoki, Kwekel, Joshua C, Burgoon, Lyle D, Dere, Edward, Williams, Kurt J, Tashiro, Colleen, Chittim, Brock, Zacharewski, Timothy R
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2577663/
https://ncbi.nlm.nih.gov/pubmed/18925944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-9-487
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