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Intracellular degradation of misfolded proteins in polyglutamine neurodegenerative diseases

A number of neurodegenerative diseases, including Alzheimer’s, Parkinson’s, and polyglutamine diseases, are characterized by the age-dependent formation of intracellular protein aggregates and neurodegeneration. Although there is some debate surrounding the role of these aggregates in neurotoxicity,...

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Bibliographic Details
Main Authors: Li, Xiang, Li, He, Li, Xiao-Jiang
Format: Artigo
Language:Inglês
Published: 2008
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2577582/
https://ncbi.nlm.nih.gov/pubmed/18773920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainresrev.2008.08.003
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