DNA hypomethylation arises later in prostate cancer progression than CpG island hypermethylation and contributes to metastatic tumor heterogeneity

Hypomethylation of CpG dinucleotides in genomic DNA was one of the first somatic epigenetic alterations discovered in human cancers. DNA hypomethylation is postulated to occur very early in almost all human cancers, perhaps facilitating genetic instability and cancer initiation and progression. We t...

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Detalhes bibliográficos
Main Authors: Yegnasubramanian, Srinivasan, Haffner, Michael C., Zhang, Yonggang, Gurel, Bora, Cornish, Toby C., Wu, Zhijin, Irizarry, Rafael, Morgan, James, Hicks, Jessica, DeWeese, Theodore L., Isaacs, William B., Bova, G. Steven, De Marzo, Angelo M., Nelson, William G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2577392/
https://ncbi.nlm.nih.gov/pubmed/18974140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-07-6088
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