Impact of non-homologous end-joining deficiency on random and targeted DNA integration: implications for gene targeting

In higher animal cells, the principal limitation of gene-targeting technology is the extremely low efficiency of targeted integration, which occurs three to four orders of magnitude less frequently than random integration. Assuming that random integration mechanistically involves non-homologous end-...

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Detalhes bibliográficos
Main Authors: Iiizumi, Susumu, Kurosawa, Aya, So, Sairei, Ishii, Yasuyuki, Chikaraishi, Yuichi, Ishii, Ayako, Koyama, Hideki, Adachi, Noritaka
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2008
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2577324/
https://ncbi.nlm.nih.gov/pubmed/18835848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn649
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