An Integrated, Directed Mass Spectrometric Approach for In-depth Characterization of Complex Peptide Mixtures

LC-MS/MS has emerged as the method of choice for the identification and quantification of protein sample mixtures. For very complex samples such as complete proteomes, the most commonly used LC-MS/MS method, data-dependent acquisition (DDA) precursor selection, is of limited utility. The limited sca...

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Autori principali: Schmidt, Alexander, Gehlenborg, Nils, Bodenmiller, Bernd, Mueller, Lukas N., Campbell, Dave, Mueller, Markus, Aebersold, Ruedi, Domon, Bruno
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2008
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2577211/
https://ncbi.nlm.nih.gov/pubmed/18511481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M700498-MCP200
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