Targeting ErbB2 and ErbB3 with a bispecific single-chain Fv enhances targeting selectivity and induces a therapeutic effect in vitro

Inappropriate signalling through the EGFR and ErbB2/HER2 members of the epidermal growth factor family of receptor tyrosine kinases is well recognised as being causally linked to a variety of cancers. Consequently, monoclonal antibodies specific for these receptors have become increasingly important...

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Main Authors: Robinson, M K, Hodge, K M, Horak, E, Sundberg, Å L, Russeva, M, Shaller, C C, von Mehren, M, Shchaveleva, I, Simmons, H H, Marks, J D, Adams, G P
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2008
Teme:
Clinical Study
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2576487/
https://ncbi.nlm.nih.gov/pubmed/18841159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604700
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