The V1-V3 region of a brain-derived HIV-1 envelope glycoprotein determines macrophage tropism, low CD4 dependence, increased fusogenicity and altered sensitivity to entry inhibitors

BACKGROUND: HIV-1 infects macrophages and microglia in the brain and can cause neurological disorders in infected patients. We and others have shown that brain-derived envelope glycoproteins (Env) have lower CD4 dependence and higher avidity for CD4 than those from peripheral isolates, and we have a...

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Bibliographic Details
Main Authors: Rossi, Fiorella, Querido, Bianca, Nimmagadda, Manideepthi, Cocklin, Simon, Navas-Martín, Sonia, Martín-García, Julio
Format: Artigo
Language:Inglês
Published: BioMed Central 2008
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2576352/
https://ncbi.nlm.nih.gov/pubmed/18837996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-5-89
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