Identifying intrinsic and extrinsic determinants that regulate internal initiation of translation mediated by the FMR1 5' leader

BACKGROUND: Regulating synthesis of the Fragile X gene (FMR1) product, FMRP alters neural plasticity potentially through its role in the microRNA pathway. Cap-dependent translation of the FMR1 mRNA, a process requiring ribosomal scanning through the 5' leader, is likely impeded by the extensive...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Dobson, Tara, Kube, Erika, Timmerman, Stephanie, Krushel, Les A
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BioMed Central 2008
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2576346/
https://ncbi.nlm.nih.gov/pubmed/18922172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2199-9-89
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