Identifying intrinsic and extrinsic determinants that regulate internal initiation of translation mediated by the FMR1 5' leader

BACKGROUND: Regulating synthesis of the Fragile X gene (FMR1) product, FMRP alters neural plasticity potentially through its role in the microRNA pathway. Cap-dependent translation of the FMR1 mRNA, a process requiring ribosomal scanning through the 5' leader, is likely impeded by the extensive...

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Detalhes bibliográficos
Main Authors: Dobson, Tara, Kube, Erika, Timmerman, Stephanie, Krushel, Les A
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2576346/
https://ncbi.nlm.nih.gov/pubmed/18922172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2199-9-89
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