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Convulsive liability of bupropion hydrochloride metabolites in Swiss albino mice

BACKGROUND: It is known that following chronic dosing with bupropion HCl active metabolites are present in plasma at levels that are several times higher than that of the parent drug, but the possible convulsive effects of the major metabolites are not known. METHODS: We investigated the convulsive...

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Autores principales: Silverstone, Peter H, Williams, Robert, McMahon, Louis, Fleming, Rosanna, Fogarty, Siobhan
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2008
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2576274/
https://ncbi.nlm.nih.gov/pubmed/18922171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-859X-7-19
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